Regulation of calcium ion import

Across TCGA patient cohorts, RNA activity of the Regulation of calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRBV5-4, LIMA1, and TNNC2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion import activity versus TRBV5-4 in PDAC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TRBV5-4 →	-0.996	-0.160	<.001	<.001	3	3
PDAC	LIMA1 →	+0.369	+0.112	<.001	<.001	3	3
HNSC	TNNC2 →	+1.845	+0.169	.003	.008	3	3
HNSC	PDLIM3 →	+1.458	+0.193	<.001	.002	3	3
CCRCC	RPL22P3 →	+0.332	+0.338	.007	.005	3	3
GBM	NOXRED1 →	+0.384	+0.555	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090279 vs TRBV5-4 — PDAC

Explore this scatter interactively →