Regulation of calcium ion import

Across TCGA cell cohorts, RNA activity of the Regulation of calcium ion import pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMARCA5, CTNNB1, and CASR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMARCA5 grouped by Regulation of calcium ion import-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SMARCA5 →	-0.257	-0.855	.004	.004	3	5
LARGE_INTESTINE	CTNNB1 →	-1.414	-0.500	<.001	<.001	3	5
LUNG_NSCLC_LUAD	CASR →	-0.189	-0.798	<.001	<.001	3	4
SKIN	SLC39A11 →	-0.297	-1.110	.009	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MCM6 →	+0.346	+1.278	.008	.001	2	5
LUNG_SCLC	PPHLN1 →	+0.136	+0.712	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMARCA5 by Regulation of calcium ion import activity — SKIN

Explore this box plot interactively →