Regulation of calcium ion import

Across TCGA cell cohorts, RNA activity of the Regulation of calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX5A, ARRB1, and KDM6B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX5A grouped by Regulation of calcium ion import-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	COX5A →	+0.916	+1.059	.004	.003	3	4
LIVER	ARRB1 →	+2.236	+1.320	.004	.006	3	4
BONE	KDM6B →	+1.029	+1.078	<.001	.004	3	4
LARGE_INTESTINE	DUSP5 →	-2.215	-0.546	<.001	.006	3	4
LARGE_INTESTINE	CDX2 →	+2.679	+0.778	.001	.005	3	4
LUNG_SCLC	PDE6A →	-0.372	-1.058	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX5A by Regulation of calcium ion import activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →