Regulation of calcium ion import

Across TCGA cell cohorts, RNA activity of the Regulation of calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRNP, SAPCD1, and FGFR4, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion import activity versus PRNP in SOFT_TISSUE (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PRNP →	+1.695	+0.194	<.001	<.001	3	11
PANCREAS	SAPCD1 →	-1.196	-0.085	<.001	.007	3	10
SOFT_TISSUE	FGFR4 →	-2.375	-0.103	<.001	.001	3	10
BONE	MVP →	+2.708	+0.171	<.001	<.001	3	10
SOFT_TISSUE	ARHGEF39 →	-1.005	-0.128	<.001	.001	3	10
KIDNEY	CAMSAP3 →	-1.225	-0.084	.005	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090279 vs PRNP — SOFT_TISSUE

Explore this scatter interactively →