Regulation of calcium ion import

Across TCGA cell cohorts, RNA activity of the Regulation of calcium ion import pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC15, LGALS1, and SRPX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of calcium ion import activity versus DNAJC15 in LIVER (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DNAJC15 →	+2.432	+0.357	.001	.007	3	5
BONE	LGALS1 →	+3.843	+1.383	.001	.006	3	4
LIVER	SRPX2 →	+4.232	+0.562	.001	.006	3	4
BONE	FBL →	-0.829	-1.023	<.001	.005	3	4
BONE	TWNK →	-1.219	-1.596	<.001	.008	3	4
BONE	METTL2B →	-0.769	-1.067	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090279 vs DNAJC15 — LIVER

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