Positive regulation of mitotic cell cycle spindle assembly checkpoint

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitotic cell cycle spindle assembly checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN3, VRK1, and MYBL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic cell cycle spindle assembly checkpoint activity versus CDKN3 in BRCA (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDKN3 →	+0.777	+0.845	<.001	<.001	3	5
LSCC	VRK1 →	+0.759	+0.560	<.001	<.001	3	5
BRCA	MYBL2 →	+1.332	+0.676	<.001	<.001	3	5
LSCC	GMNN →	+0.745	+0.699	<.001	<.001	3	5
BRCA	CDC20 →	+1.480	+0.953	<.001	<.001	3	5
BRCA	NEK2 →	+1.064	+0.813	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090267 vs CDKN3 — BRCA

Explore this scatter interactively →