Positive regulation of mitotic cell cycle spindle assembly checkpoint

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic cell cycle spindle assembly checkpoint pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AURKB, BIRC5, and INCENP, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AURKB grouped by Positive regulation of mitotic cell cycle spindle assembly checkpoint-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AURKB →	-0.383	-0.214	.003	<.001	3	12
STOMACH	BIRC5 →	-0.570	-0.188	.002	.009	3	11
KIDNEY	INCENP →	-0.333	-0.263	<.001	<.001	3	9
KIDNEY	TTK →	-0.429	-0.267	.001	.001	3	4
KIDNEY	MRE11 →	+0.183	+0.235	.002	.001	3	4
KIDNEY	ATP8B1 →	-0.121	-0.197	.008	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AURKB by Positive regulation of mitotic cell cycle spindle assembly checkpoint activity — OVARY

Explore this box plot interactively →