Positive regulation of mitotic cell cycle spindle assembly checkpoint

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic cell cycle spindle assembly checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UHRF1, PHLDA3, and MYL6B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic cell cycle spindle assembly checkpoint activity versus UHRF1 in BLOOD_Leukemia (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UHRF1 →	+2.121	+0.555	<.001	<.001	3	6
LUNG_NSCLC_LUAD	PHLDA3 →	-0.977	-0.605	.006	.001	3	6
BLOOD_Leukemia	MYL6B →	+0.877	+0.556	<.001	<.001	3	5
URINARY_TRACT	SPAG5 →	+1.388	+1.567	.005	.002	3	5
PANCREAS	TMEM265 →	-1.807	-0.884	<.001	.002	3	5
BLOOD_Leukemia	SMARCD1 →	+1.288	+0.766	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090267 vs UHRF1 — BLOOD_Leukemia

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