Regulation of muscle system process

Across TCGA patient cohorts, RNA activity of the Regulation of muscle system process pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEAK1, NEDD9, and AKAP12, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of muscle system process activity versus PEAK1 in THYM (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	PEAK1 →	+1.225	+0.025	<.001	<.001	3	30
PCPG	NEDD9 →	+1.491	+0.027	<.001	<.001	3	29
THYM	AKAP12 →	+1.876	+0.020	<.001	<.001	3	29
CHOL	THBS1 →	+1.993	+0.023	<.001	<.001	3	29
UVM	UACA →	+1.370	+0.012	<.001	<.001	3	29
THYM	ARHGAP29 →	+1.765	+0.022	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090257 vs PEAK1 — THYM

Explore this scatter interactively →