Regulation of muscle system process

Across TCGA patient cohorts, RNA activity of the Regulation of muscle system process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGHV7-81, DDX11L8, and KRT20, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of muscle system process activity versus IGHV7-81 in BRCA (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGHV7-81 →	-0.970	-0.332	.001	.007	2	1
BRCA	DDX11L8 →	-0.603	-0.206	.004	<.001	2	1
BRCA	KRT20 →	-0.140	-0.153	.008	.006	1	1
BRCA	HM13-AS1 →	-0.310	-0.118	<.001	.008	1	1
BRCA	SULT1C2P2 →	-0.483	-0.311	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest associations by consensus.

GO:0090257 vs IGHV7-81 — BRCA

Explore this scatter interactively →