Regulation of muscle system process

Across TCGA cell cohorts, RNA activity of the Regulation of muscle system process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf116, DLG4, and KCNK1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of muscle system process activity versus C1orf116 in URINARY_TRACT (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	C1orf116 →	+3.890	+0.496	<.001	<.001	3	8
STOMACH	DLG4 →	-2.908	-0.203	<.001	.005	3	7
URINARY_TRACT	KCNK1 →	+2.476	+0.374	.002	.001	3	7
STOMACH	LGALS9 →	+3.368	+0.203	<.001	.001	3	6
STOMACH	PRR15 →	+3.531	+0.240	<.001	.009	3	6
URINARY_TRACT	PRRG2 →	+2.357	+0.369	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090257 vs C1orf116 — URINARY_TRACT

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