Regulation of arachidonic acid secretion

Across TCGA patient cohorts, RNA activity of the Regulation of arachidonic acid secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DLGAP4_T915, KIF2C, and TOP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of arachidonic acid secretion activity versus DLGAP4_T915 in LUAD (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DLGAP4_T915 →	-1.017	-0.121	<.001	<.001	3	6
BRCA	KIF2C →	-0.625	-0.099	<.001	<.001	3	6
LUAD	TOP1 →	-0.323	-0.099	.003	.007	3	6
LUAD	GAS2L3_S431 →	-0.853	-0.094	<.001	.002	3	6
LUAD	MKI67_S357 →	-1.081	-0.116	<.001	<.001	3	6
UCEC	CDC20_T70 →	-0.943	-0.156	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090237 vs DLGAP4_T915 — LUAD

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