Regulation of metaphase plate congression

Across TCGA cell cohorts, RNA activity of the Regulation of metaphase plate congression pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPB41L1, CASP10, and PLAAT4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of metaphase plate congression activity versus EPB41L1 in BREAST (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	EPB41L1 →	-1.579	-0.155	<.001	.004	3	5
BLOOD_Myeloma	CASP10 →	-0.852	-0.199	.007	.003	3	5
OVARY	PLAAT4 →	-2.992	-0.168	.001	.006	3	4
PANCREAS	CTSH →	-2.278	-0.130	.006	.003	3	4
BLOOD_Lymphoma	PARP9 →	-2.353	-0.241	<.001	<.001	3	4
BLOOD_Leukemia	MME →	+2.213	+0.126	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090235 vs EPB41L1 — BREAST

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