Negative regulation of triglyceride metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of triglyceride metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SULT1A4, MCRS1, and FAM189B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of triglyceride metabolic process activity versus SULT1A4 in PANCREAS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SULT1A4 →	+2.924	+0.213	.005	.003	3	5
LUNG_NSCLC_LUAD	MCRS1 →	-0.588	-0.137	<.001	<.001	3	5
LUNG_SCLC	FAM189B →	-0.858	-0.181	.003	.009	3	5
PANCREAS	MLF2 →	-0.816	-0.228	.009	.004	3	4
OESOPHAGUS	AZI2 →	-0.692	-0.234	.005	.002	3	4
LUNG_NSCLC_LUSC	AVL9 →	-1.081	-0.244	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090209 vs SULT1A4 — PANCREAS

Explore this scatter interactively →