Positive regulation of triglyceride metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of triglyceride metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR25, GPSM2, and POLE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR25 grouped by Positive regulation of triglyceride metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GPR25 →	+0.188	+1.556	.006	.001	3	4
BLOOD_Lymphoma	GPSM2 →	+0.388	+0.419	.001	.001	3	4
PANCREAS	POLE →	+0.275	+1.041	.001	.004	3	4
LIVER	BSG →	-0.306	-1.556	.002	.001	3	3
LIVER	MESP2 →	-0.168	-1.556	.002	.001	3	3
LIVER	SETSIP →	+0.335	+1.724	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR25 by Positive regulation of triglyceride metabolic process activity — LIVER

Explore this box plot interactively →