Positive regulation of triglyceride metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of triglyceride metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCARB1, PHF20, and GPATCH11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of triglyceride metabolic process activity versus SCARB1 in SOFT_TISSUE (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SCARB1 →	+2.338	+1.270	<.001	.002	3	5
LIVER	PHF20 →	-0.811	-1.305	<.001	.008	3	4
SOFT_TISSUE	GPATCH11 →	-0.902	-1.487	.005	.002	3	4
UPPER_AERODIGESTIVE_TRACT	VTI1B →	-0.953	-1.540	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	C21orf58 →	-1.569	-1.323	.001	.005	3	4
LUNG_NSCLC_LUAD	ARHGAP33 →	-0.728	-0.828	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090208 vs SCARB1 — SOFT_TISSUE

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