Regulation of triglyceride metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of triglyceride metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SASH3_S97, ATAD2_S342, and TRIM33_S862, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of triglyceride metabolic process activity versus SASH3_S97 in OV (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SASH3_S97 →	+1.078	+0.046	<.001	.001	3	6
LUAD	ATAD2_S342 →	-1.120	-0.044	<.001	<.001	3	6
BRCA	TRIM33_S862 →	-0.533	-0.026	.001	.006	3	6
LUAD	CDK1 →	-0.644	-0.040	<.001	<.001	3	6
LUAD	SUSD2 →	+0.538	+0.044	.001	.001	3	5
LUAD	UBAP2 →	-0.344	-0.050	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090207 vs SASH3_S97 — OV

Explore this scatter interactively →