Negative regulation of release of cytochrome c from mitochondria

Across TCGA patient cohorts, RNA activity of the Negative regulation of release of cytochrome c from mitochondria pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMP1, UACA, and TGFB1I1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of release of cytochrome c from mitochondria activity versus EMP1 in LUAD (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EMP1 →	+0.938	+0.292	<.001	<.001	3	6
GBM	UACA →	+0.559	+0.184	<.001	.001	3	6
BRCA	TGFB1I1 →	+1.198	+0.304	<.001	<.001	3	6
BRCA	CAVIN1 →	+0.874	+0.234	<.001	<.001	3	6
BRCA	SYDE1 →	+0.652	+0.235	<.001	<.001	3	6
BRCA	IGFBP7 →	+0.625	+0.283	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090201 vs EMP1 — LUAD

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