Negative regulation of release of cytochrome c from mitochondria

Across TCGA cell cohorts, RNA activity of the Negative regulation of release of cytochrome c from mitochondria pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UNC5CL, PLA2R1, and LRRC42, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UNC5CL grouped by Negative regulation of release of cytochrome c from mitochondria-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UNC5CL →	+1.302	+1.008	.009	.002	3	5
OESOPHAGUS	PLA2R1 →	+1.606	+0.266	.003	.003	3	5
BLOOD_Leukemia	LRRC42 →	+0.926	+1.555	.002	<.001	3	4
LARGE_INTESTINE	EPS8L3 →	+3.333	+1.303	.001	.001	3	4
LARGE_INTESTINE	CFB →	+2.033	+1.281	.003	.001	3	4
LARGE_INTESTINE	DTX2 →	+1.005	+0.758	.004	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UNC5CL by Negative regulation of release of cytochrome c from mitochondria activity — LARGE_INTESTINE

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