Regulation of release of cytochrome c from mitochondria

Across TCGA cell cohorts, RNA activity of the Regulation of release of cytochrome c from mitochondria pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1A, TMEM245, and UCK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN1A grouped by Regulation of release of cytochrome c from mitochondria-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDKN1A →	-1.894	-0.947	.008	.007	3	5
LUNG_NSCLC_LUAD	TMEM245 →	+0.865	+0.235	<.001	<.001	3	5
KIDNEY	UCK1 →	+0.635	+0.893	.001	.004	3	4
LUNG_NSCLC_LUAD	PPP1R12A →	+0.389	+0.151	.008	.004	3	4
LUNG_NSCLC_LUAD	HUWE1 →	+0.416	+0.158	.006	.002	3	4
SOFT_TISSUE	CNKSR3 →	+1.773	+1.576	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN1A by Regulation of release of cytochrome c from mitochondria activity — SKIN

Explore this box plot interactively →