Regulation of branching involved in ureteric bud morphogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of branching involved in ureteric bud morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMO, BMP4, and EML4, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of branching involved in ureteric bud morphogenesis activity versus SMO in KICH (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	SMO →	+1.639	+0.083	<.001	<.001	3	23
THYM	BMP4 →	+1.824	+0.053	<.001	<.001	3	19
THYM	EML4 →	+0.623	+0.065	<.001	<.001	3	18
THYM	LRP5 →	+1.193	+0.079	<.001	<.001	3	17
TGCT	MTA1 →	+0.641	+0.059	<.001	<.001	3	17
KIRP	TEN1-CDK3 →	+0.578	+0.066	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090189 vs SMO — KICH

Explore this scatter interactively →