Regulation of pancreatic juice secretion

Across TCGA patient cohorts, RNA activity of the Regulation of pancreatic juice secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FLI1_S39, ZAP70, and DEF6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pancreatic juice secretion activity versus FLI1_S39 in LSCC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FLI1_S39 →	+0.445	+0.069	<.001	<.001	3	6
LSCC	ZAP70 →	+0.589	+0.084	<.001	<.001	3	6
BRCA	DEF6 →	+0.328	+0.059	<.001	<.001	3	6
LUAD	DOCK2_S1706 →	+0.819	+0.090	<.001	<.001	3	6
UCEC	APOL3 →	+0.756	+0.143	<.001	<.001	3	6
LSCC	NADK_S46 →	+0.831	+0.081	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090186 vs FLI1_S39 — LSCC

Explore this scatter interactively →