Regulation of pancreatic juice secretion

Across TCGA patient cohorts, RNA activity of the Regulation of pancreatic juice secretion pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C10orf99, ARL1, and SPIDR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pancreatic juice secretion activity versus C10orf99 in COAD (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C10orf99 →	+1.805	+0.205	<.001	.001	3	4
GBM	ARL1 →	+0.282	+0.593	.001	.001	3	3
PDAC	SPIDR →	+0.248	+0.562	.001	.006	3	3
UCEC	RMDN3 →	+0.286	+0.684	.005	.004	3	3
LUAD	SNX25 →	+0.572	+0.389	.003	.002	3	3
LUAD	TAC4 →	+0.726	+0.401	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090186 vs C10orf99 — COAD

Explore this scatter interactively →