Regulation of pancreatic juice secretion

Across TCGA cell cohorts, RNA activity of the Regulation of pancreatic juice secretion pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFITM2, MSH2, and PMPCA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFITM2 grouped by Regulation of pancreatic juice secretion-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	IFITM2 →	-3.251	-1.579	.005	<.001	3	4
BLOOD_Leukemia	MSH2 →	+0.974	+1.223	.004	.005	3	4
PANCREAS	PMPCA →	-0.914	-1.053	.003	.003	3	4
URINARY_TRACT	STC1 →	-3.417	-1.264	.003	.007	3	4
KIDNEY	BBS5 →	-0.955	-1.063	<.001	.007	3	4
SOFT_TISSUE	RALY →	+0.830	+1.650	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFITM2 by Regulation of pancreatic juice secretion activity — LIVER

Explore this box plot interactively →