Regulation of cholesterol metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of cholesterol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RMDN2, MRTO4, and RCOR1_S127, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cholesterol metabolic process activity versus RMDN2 in LUAD (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RMDN2 →	+0.674	+0.055	<.001	<.001	3	7
BRCA	MRTO4 →	-0.481	-0.054	<.001	<.001	3	7
LSCC	RCOR1_S127 →	-0.645	-0.052	<.001	<.001	2	7
BRCA	RRP9 →	-0.324	-0.052	<.001	<.001	3	6
BRCA	RSF1_S397 →	-0.854	-0.037	<.001	<.001	3	6
BRCA	RSU1 →	+0.383	+0.039	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090181 vs RMDN2 — LUAD

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