Regulation of cholesterol metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of cholesterol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPIN1, C3orf38, and RIN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPIN1 grouped by Regulation of cholesterol metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SPIN1 →	-0.745	-0.858	<.001	<.001	3	3
CNS	C3orf38 →	-0.676	-0.931	.003	.004	3	3
LUNG_SCLC	RIN2 →	-1.263	-0.569	.006	.005	3	3
KIDNEY	RPL39L →	+3.166	+1.069	.002	.002	3	3
OESOPHAGUS	PARVB →	-2.465	-0.290	.003	<.001	2	4
BONE	CHAMP1 →	+0.815	+1.468	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPIN1 by Regulation of cholesterol metabolic process activity — OVARY

Explore this box plot interactively →