Regulation of cholesterol metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of cholesterol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCD, LPCAT3, and STARD4, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cholesterol metabolic process activity versus SCD in LUNG_NSCLC_LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SCD →	+1.559	+0.067	.002	.006	2	14
KIDNEY	LPCAT3 →	+1.294	+0.091	<.001	<.001	3	12
SOFT_TISSUE	STARD4 →	+1.750	+0.089	.001	<.001	3	11
PANCREAS	FDFT1 →	+1.139	+0.093	.008	.001	2	11
KIDNEY	LDLR →	+2.963	+0.103	<.001	<.001	3	10
STOMACH	SREBF2 →	+1.072	+0.119	.002	.006	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090181 vs SCD — LUNG_NSCLC_LUAD

Explore this scatter interactively →