Regulation of cholesterol metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of cholesterol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPM1F, ERLIN1, and ARHGEF38, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cholesterol metabolic process activity versus PPM1F in BREAST (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PPM1F →	+0.998	+0.291	.001	<.001	3	5
BLOOD_Leukemia	ERLIN1 →	+1.166	+0.331	.004	<.001	3	5
BREAST	ARHGEF38 →	-1.363	-0.264	.006	.006	3	5
STOMACH	CYTH1 →	-0.790	-0.211	<.001	.001	3	5
LIVER	SELENOM →	+4.108	+0.309	.002	.003	3	5
LUNG_NSCLC_LUAD	PHTF2 →	+0.887	+0.235	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090181 vs PPM1F — BREAST

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