Establishment of epithelial cell polarity

Across TCGA cell cohorts, RNA activity of the Establishment of epithelial cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XXYLT1, ZNF493, and HS6ST2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XXYLT1 grouped by Establishment of epithelial cell polarity-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	XXYLT1 →	-1.062	-1.548	.008	<.001	3	4
OESOPHAGUS	ZNF493 →	-1.378	-1.395	.003	.004	3	4
URINARY_TRACT	HS6ST2 →	-3.556	-1.484	<.001	<.001	3	3
SOFT_TISSUE	NCR3LG1 →	-1.240	-1.254	.002	<.001	3	3
SOFT_TISSUE	AP2S1 →	+0.961	+1.334	.004	.007	3	3
PANCREAS	BCAT2 →	-0.906	-0.618	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XXYLT1 by Establishment of epithelial cell polarity activity — URINARY_TRACT

Explore this box plot interactively →