Establishment of epithelial cell polarity

Across TCGA cell cohorts, RNA activity of the Establishment of epithelial cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSN, ACSF2, and MRPS26, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of epithelial cell polarity activity versus MSN in LUNG_SCLC (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MSN →	+3.866	+0.245	<.001	<.001	3	5
STOMACH	ACSF2 →	-1.533	-0.254	.008	.001	3	5
LUNG_SCLC	MRPS26 →	-0.616	-0.171	.004	.007	3	4
URINARY_TRACT	SPINT2 →	-3.455	-0.345	.001	.009	3	4
LIVER	IFNGR2 →	+1.025	+0.236	.005	.002	3	4
OVARY	CRIM1 →	+2.343	+0.275	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090162 vs MSN — LUNG_SCLC

Explore this scatter interactively →