Golgi ribbon formation

Across TCGA patient cohorts, RNA activity of the Golgi ribbon formation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FHDC1_S500, KIF23_S902, and CAMK1D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi ribbon formation activity versus FHDC1_S500 in HNSC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FHDC1_S500 →	+0.677	+0.070	.001	.004	3	5
BRCA	KIF23_S902 →	-0.705	-0.051	.004	.003	3	5
GBM	CAMK1D →	+0.396	+0.069	.002	.001	3	5
GBM	SPCS3 →	-0.305	-0.060	<.001	.002	3	4
CCRCC	ABLIM3_S503 →	+0.653	+0.044	.006	.006	2	5
BRCA	CNKSR1 →	+0.272	+0.035	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090161 vs FHDC1_S500 — HNSC

Explore this scatter interactively →