Golgi to lysosome transport

Across TCGA patient cohorts, RNA activity of the Golgi to lysosome transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNPY4, MRPL4, and PCOLCE, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi to lysosome transport activity versus CNPY4 in UCEC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CNPY4 →	+0.324	+0.056	<.001	.002	3	8
LSCC	MRPL4 →	-0.278	-0.049	<.001	.003	3	6
BRCA	PCOLCE →	+0.525	+0.036	<.001	<.001	3	6
PDAC	HIP1 →	+0.298	+0.039	<.001	.002	3	6
CCRCC	C1QA →	+0.624	+0.046	.002	.002	3	5
OV	C1R →	+0.630	+0.063	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090160 vs CNPY4 — UCEC

Explore this scatter interactively →