Golgi to lysosome transport

Across TCGA pan-cancer cohorts, RNA activity of the Golgi to lysosome transport pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Golgi to lysosome transport pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and ACC, show the opposite pattern, with higher activity associated with better survival.

HNSC, LGG, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.643	0.499	.001	92	view →
LGG	DFS	Median	All	0.644	0.799	<.001	52	view →
MESO	DFS	Tertile	All	0.322	0.535	.007	36	view →
LUSC	DFS	Quartile	III,IV	0.285	0.935	<.001	33	view →
ACC	OS	Median	III,IV	0.935	0.536	.004	32	view →
ESCA	DFS	Tertile	III,IV	0.476	0.242	.022	21	view →
SKCM	OS	Median	II,III,IV	0.447	0.210	.001	19	view →
UVM	DFS	Quartile	II,III,IV	0.486	0.867	.009	18	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	15	view →
THCA	OS	Median	All	0.952	0.989	.011	12	view →
COAD	DFS	Quartile	All	0.295	0.607	.008	9	view →
LIHC	DFS	Median	III,IV	0.439	0.287	.025	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0090160–HNSC (DFS)

Open the HNSC breakdown →