Golgi to lysosome transport

Across TCGA cell cohorts, RNA activity of the Golgi to lysosome transport pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IER3, TBX6, and PEBP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IER3 grouped by Golgi to lysosome transport-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IER3 →	-1.623	-1.170	.004	.006	3	4
KIDNEY	TBX6 →	+0.545	+1.547	.001	<.001	3	4
SKIN	PEBP1 →	-0.729	-0.909	.004	.008	3	4
LIVER	RRM1 →	-0.979	-2.135	<.001	<.001	3	4
STOMACH	NIBAN2 →	+1.385	+1.034	.001	.002	3	3
PANCREAS	UBXN6 →	-0.530	-0.932	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IER3 by Golgi to lysosome transport activity — KIDNEY

Explore this box plot interactively →