Golgi to lysosome transport

Across TCGA cell cohorts, RNA activity of the Golgi to lysosome transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBSN, NR2C2, and SORT1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi to lysosome transport activity versus RBSN in LIVER (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RBSN →	+1.005	+0.114	.001	.004	2	16
LIVER	NR2C2 →	+1.248	+0.135	<.001	<.001	3	15
BLOOD_Leukemia	SORT1 →	+1.621	+0.073	<.001	<.001	3	15
LIVER	BRPF1 →	+1.226	+0.151	<.001	<.001	3	13
LIVER	EAF1 →	+0.878	+0.092	.006	.004	2	14
OVARY	INPP5K →	+0.830	+0.089	.001	.001	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090160 vs RBSN — LIVER

Explore this scatter interactively →