Endoplasmic reticulum membrane organization

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAPDHP20, DICER1-AS1, and ZCWPW1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum membrane organization activity versus GAPDHP20 in GBM (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GAPDHP20 →	+0.424	+0.159	.002	<.001	3	4
GBM	DICER1-AS1 →	+0.382	+0.171	<.001	.003	3	4
GBM	ZCWPW1 →	+0.491	+0.191	<.001	<.001	3	4
COAD	MAILR →	+0.286	+0.131	.008	.008	3	4
LUAD	SLC2A11 →	+0.422	+0.205	.002	<.001	3	3
LUAD	LINC01559 →	-0.574	-0.138	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090158 vs GAPDHP20 — GBM

Explore this scatter interactively →