Regulation of sphingolipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of sphingolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUDT7, ZNF408, and ARHGAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sphingolipid biosynthetic process activity versus NUDT7 in LARGE_INTESTINE (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NUDT7 →	+1.045	+0.250	<.001	.007	3	4
OVARY	ZNF408 →	+0.737	+0.286	<.001	.002	3	3
OVARY	ARHGAP1 →	+0.869	+0.286	<.001	.002	3	3
SOFT_TISSUE	ASMTL →	-1.727	-0.276	.007	.005	3	3
LUNG_SCLC	TBCC →	+0.601	+0.302	.004	.003	3	3
BLOOD_Myeloma	HINT2 →	+0.745	+0.271	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090153 vs NUDT7 — LARGE_INTESTINE

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