Positive regulation of mitochondrial fission

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitochondrial fission pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIPK2B, ADGRG5, and FAM241A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial fission activity versus DIPK2B in UCEC (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DIPK2B →	-0.733	-0.185	<.001	.001	3	6
PDAC	ADGRG5 →	-0.518	-0.194	<.001	.002	3	5
CCRCC	FAM241A →	-0.487	-0.187	.004	.004	3	4
CCRCC	PALM2AKAP2 →	-0.441	-0.196	<.001	.001	3	4
OV	CSF1 →	-0.798	-0.219	.008	.004	3	4
UCEC	KDR →	-0.637	-0.208	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090141 vs DIPK2B — UCEC

Explore this scatter interactively →