Regulation of synapse maturation

Across TCGA patient cohorts, RNA activity of the Regulation of synapse maturation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, CDYL_S216, and CHAF1B_S410, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synapse maturation activity versus SMC2 in LSCC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC2 →	+0.446	+0.068	<.001	<.001	3	7
BRCA	CDYL_S216 →	+0.759	+0.051	<.001	<.001	3	6
LUAD	CHAF1B_S410 →	+0.746	+0.073	<.001	<.001	3	6
LSCC	DOCK8_S904 →	-0.679	-0.055	<.001	<.001	3	6
GBM	TRADD →	-0.255	-0.038	<.001	.006	3	6
LUAD	NCOA7_S89 →	-0.538	-0.052	.006	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090128 vs SMC2 — LSCC

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