Regulation of synapse maturation

Across TCGA cell cohorts, RNA activity of the Regulation of synapse maturation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAPPC9, NABP1, and PEMT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRAPPC9 grouped by Regulation of synapse maturation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TRAPPC9 →	+1.053	+1.087	.001	.001	3	6
LUNG_NSCLC_LUAD	NABP1 →	-1.284	-0.915	.001	.002	3	5
SOFT_TISSUE	PEMT →	+0.898	+1.249	.006	.008	3	5
UPPER_AERODIGESTIVE_TRACT	CAV1 →	-2.292	-2.041	.009	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PRXL2C →	-0.689	-1.557	.002	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ZNF26 →	-1.335	-2.027	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRAPPC9 by Regulation of synapse maturation activity — OESOPHAGUS

Explore this box plot interactively →