Regulation of synapse maturation

Across TCGA cell cohorts, RNA activity of the Regulation of synapse maturation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHCBP1, GTPBP6, and LYRM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synapse maturation activity versus SHCBP1 in SKIN (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SHCBP1 →	+0.802	+0.220	.002	.001	3	6
LUNG_SCLC	GTPBP6 →	+0.907	+0.231	.005	<.001	3	4
LIVER	LYRM1 →	-0.784	-0.331	.001	.002	3	4
URINARY_TRACT	AP2M1 →	+0.867	+0.240	.004	.003	3	4
SOFT_TISSUE	NF2 →	+1.699	+0.288	.008	.006	3	4
CNS	CMTM4 →	+1.004	+0.278	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090128 vs SHCBP1 — SKIN

Explore this scatter interactively →