Vesicle-mediated cholesterol transport

Across TCGA patient cohorts, RNA activity of the Vesicle-mediated cholesterol transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S2271, PARP4, and SEPTIN4_S432, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle-mediated cholesterol transport activity versus MAP1B_S2271 in LSCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B_S2271 →	+0.947	+0.071	.001	<.001	3	5
HNSC	PARP4 →	-0.312	-0.063	<.001	.002	3	5
GBM	SEPTIN4_S432 →	+0.664	+0.051	<.001	<.001	3	5
BRCA	AKAP12_S612 →	+1.082	+0.050	<.001	<.001	3	5
BRCA	ALDH1A1_S413 →	+1.141	+0.057	<.001	<.001	3	5
GBM	HSPA12A →	+0.755	+0.075	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090119 vs MAP1B_S2271 — LSCC

Explore this scatter interactively →