Vesicle-mediated cholesterol transport

Across TCGA cell cohorts, RNA activity of the Vesicle-mediated cholesterol transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNA2, KLRG1, and GTF3C5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNA2 grouped by Vesicle-mediated cholesterol transport-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA2 →	+0.787	+1.192	<.001	.001	3	5
KIDNEY	KLRG1 →	+0.504	+0.974	.007	.005	3	4
UPPER_AERODIGESTIVE_TRACT	GTF3C5 →	+1.144	+1.412	.002	.001	3	4
BREAST	MTA2 →	+0.512	+1.027	.006	<.001	3	4
BREAST	MED14OS →	+0.621	+1.227	.001	<.001	3	4
BLOOD_Leukemia	ZNF551 →	+1.004	+0.999	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNA2 by Vesicle-mediated cholesterol transport activity — BONE

Explore this box plot interactively →