COPII-coated vesicle budding

Across TCGA patient cohorts, RNA activity of the COPII-coated vesicle budding pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RTN1, ARFGEF3_S1991, and SEH1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, COPII-coated vesicle budding activity versus RTN1 in OV (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RTN1 →	+0.522	+0.046	.005	.004	3	5
LUAD	ARFGEF3_S1991 →	+0.485	+0.026	.005	.008	3	5
BRCA	SEH1L →	-0.114	-0.033	.001	<.001	3	5
BRCA	SORBS1 →	+0.443	+0.031	<.001	<.001	3	5
HNSC	HGF →	+1.561	+0.133	.001	.007	3	5
CCRCC	HTRA1 →	+0.818	+0.027	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090114 vs RTN1 — OV

Explore this scatter interactively →