COPII-coated vesicle budding

Across TCGA pan-cancer cohorts, RNA activity of the COPII-coated vesicle budding pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 44 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher COPII-coated vesicle budding pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and BRCA, show the opposite pattern, with higher activity associated with better survival.

CESC, KIRC, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	III,IV	0.204	0.779	<.001	54	view →
KIRC	OS	Quartile	All	0.515	0.681	.001	54	view →
KIRP	OS	Tertile	All	0.352	0.833	<.001	50	view →
UVM	DFS	Quartile	All	0.280	0.852	.001	37	view →
LUSC	OS	Tertile	III,IV	0.479	0.744	.001	36	view →
SKCM	OS	Quartile	All	0.815	0.714	.006	27	view →
BRCA	DFS	Tertile	III,IV	0.943	0.817	.006	21	view →
KICH	DFS	Quartile	II,III,IV	0.440	0.879	.021	16	view →
STAD	OS	Quartile	II,III,IV	0.572	0.824	.026	11	view →
COAD	OS	Tertile	All	0.868	0.711	.017	11	view →
READ	DFS	Quartile	II,III,IV	1.000	0.732	.016	8	view →
LIHC	OS	Quartile	III,IV	0.345	0.726	.012	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0090114–CESC (DFS)

Open the CESC breakdown →