COPII-coated vesicle budding

Across TCGA patient cohorts, RNA activity of the COPII-coated vesicle budding pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRM, WDPCP, and YEATS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, COPII-coated vesicle budding activity versus NRM in LSCC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NRM →	-0.422	-0.141	.001	<.001	3	4
LSCC	WDPCP →	-0.529	-0.147	<.001	<.001	3	4
LSCC	YEATS2 →	-0.634	-0.165	.009	<.001	3	4
BRCA	SPC25 →	-0.520	-0.153	<.001	<.001	3	4
BRCA	IBA57-DT →	-0.582	-0.218	<.001	<.001	3	4
LSCC	FOXO3B →	-0.440	-0.149	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090114 vs NRM — LSCC

Explore this scatter interactively →