COPII-coated vesicle budding

Across TCGA cell cohorts, RNA activity of the COPII-coated vesicle budding pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMPRSS13, ADGRF1, and SMAD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMPRSS13 grouped by COPII-coated vesicle budding-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TMPRSS13 →	+2.212	+0.491	.001	.006	3	4
LUNG_NSCLC_LUAD	ADGRF1 →	+2.341	+0.291	.001	.004	3	4
LUNG_NSCLC_LUAD	SMAD2 →	-0.859	-0.225	.002	<.001	3	4
BLOOD_Lymphoma	UBAC1 →	-0.620	-0.255	.003	.006	2	5
LUNG_SCLC	GIT2 →	-0.887	-0.342	<.001	.002	3	4
LIVER	MADD →	-1.170	-0.308	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMPRSS13 by COPII-coated vesicle budding activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →