COPII-coated vesicle cargo loading

Across TCGA patient cohorts, RNA activity of the COPII-coated vesicle cargo loading pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC24D, LMOD1, and LTBP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, COPII-coated vesicle cargo loading activity versus SEC24D in OV (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SEC24D →	+0.445	+0.080	<.001	<.001	3	8
CCRCC	LMOD1 →	+0.732	+0.044	.004	.005	3	6
GBM	LTBP2 →	+1.036	+0.082	<.001	<.001	3	6
BRCA	MSRB3 →	+0.694	+0.068	<.001	<.001	3	6
GBM	OLFML3 →	+0.810	+0.065	<.001	<.001	3	6
OV	PLAC9 →	+0.996	+0.069	.002	.007	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090110 vs SEC24D — OV

Explore this scatter interactively →