COPII-coated vesicle cargo loading

Across TCGA pan-cancer cohorts, RNA activity of the COPII-coated vesicle cargo loading pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 16 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher COPII-coated vesicle cargo loading pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and LAML, show the opposite pattern, with higher activity associated with better survival.

KIRP, CESC, and STAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.546	0.780	<.001	91	view →
CESC	DFS	Tertile	All	0.386	0.678	<.001	76	view →
STAD	DFS	Tertile	All	0.426	0.583	.004	47	view →
LUSC	DFS	Quartile	III,IV	0.477	0.789	.007	38	view →
UVM	DFS	Tertile	All	0.321	0.838	.001	36	view →
SKCM	DFS	Median	All	0.776	0.693	.006	24	view →
BLCA	DFS	Median	II,III,IV	0.461	0.553	.020	19	view →
KICH	DFS	Median	II,III,IV	0.422	0.937	.004	12	view →
CHOL	OS	Median	All	0.582	0.826	.039	11	view →
PAAD	OS	Median	All	0.523	0.712	.016	9	view →
DLBC	DFS	Median	All	0.622	1.000	.014	9	view →
HNSC	OS	Quartile	III,IV	0.453	0.749	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0090110–KIRP (OS)

Open the KIRP breakdown →