COPII-coated vesicle cargo loading

Across TCGA patient cohorts, RNA activity of the COPII-coated vesicle cargo loading pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS27P25, PPM1G, and DIPK1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, COPII-coated vesicle cargo loading activity versus RPS27P25 in HNSC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPS27P25 →	-0.394	-0.074	.009	.002	3	6
LSCC	PPM1G →	-0.583	-0.204	<.001	<.001	3	5
LSCC	DIPK1B →	-0.893	-0.233	<.001	<.001	3	5
LSCC	IGKV1-39 →	+1.186	+0.158	.001	<.001	3	5
BRCA	KAT2A →	-0.630	-0.185	<.001	<.001	3	4
LSCC	TRIM45 →	-1.043	-0.198	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090110 vs RPS27P25 — HNSC

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